본문
| Department | Biochemistry |
|---|---|
| Major Field of Research | Cancer Biology, Signal Trasnduction, Gene expression |
| ydjung@jnu.ac.kr | |
| Homepage |
Research interests
Professor Young-do Jung has interested in gene regulation, signal transduction, and transcription factors related to the occurrence and progression of gastric and colorectal cancer, and is conducting research on inhibition of regulation using natural products.
1. Occurrence of stomach and colon cancer due to inflammation and bile acids are investigated by comparing the expression of inflammatory factors and bile acids in gastric cancer and colon cancer, such as DNA and RNA microarray, genes essential for cancer development and progression: urokinase-type plasminogne receptor (uPAR), interleukin-8 (IL-8), Recepteur d'Origine The expression of genes such as Nantais (RON) was observed to be significantly increased, and their regulation is being studied.
2. Study of intracellular signaling and transcription factors related to gastric and colorectal cancer cell proliferation, invasion, and angiogenesis, such as NADPH oxidaase, mitogen-activated protein kinase, PI-3-kinase, STAT, SRC, and transcription factors activator protein-1, NF- Related studies such as kB, Egr-1, and SP-1 have been studied, and research is underway to find the promoter site to which the transcription factors bind.
3. Research with natural products on the effects of intracellular action, signal transduction pathway regulation, transcription factor regulation, cell growth and invasion by treatment with natural products that inhibit gastric cancer and colon cancer from the Korea Resources Bank. We are also interested in pursuing joint research with nanotechnology for delivary of natural products.
4. We are conducting research on the regulation of miR-21, which is known as an important onco-miR for the development of gastric cancer and colorectal cancer, and are studying the molecular level mechanisms by finding substances that promote or inhibit miR-21 expression in gastric and colon cancer cells. In addition, we are conducting research on promoter to discover transcription factors for miR-21 regulation.
Publication
- 1. Nicotine stimulates IL-6 expression by activating the AP-1 and STAT-3 pathways in human endothelial EA.hy926 cells. J Cell Biochem. 2018 Oct 14. doi: 10.1002/jcb.27837.
- 2. Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells. J Agric Food Chem. 2018 Jul 25;66(29):7663-7673
- 3. Role of Recepteur D'origine Nantais on Gastric Cancer Development and Progression. Chonnam Med J. 2017 Sep;53(3):178-186
- 4. Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity. J Cell Biochem. 2017 Sep;118(9):2958-2967.
- 5. Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. Mol Carcinog. 2017 Feb;56(2):664-680.
- 6. MicroRNA-375 Functions as a Tumor-Suppressor Gene in Gastric Cancer by Targeting Recepteur d'Origine Nantais. Int J Mol Sci. 2016 Sep 27;17(10). pii: E1633.7. Docosahexaenoic Acid Inhibits Tumor Promoter-Induced Urokinase-Type Plasminogen Activator Receptor by Suppressing PKCδ- and MAPKs-Mediated Pathways in ECV304 Human Endothelial Cells. PLoS One. 2016 Sep 21;11(9):e0163395. 8. Carbon monoxide releasing molecule-2 ameliorates IL-1β-induced IL-8 in human gastric cancer cells. Toxicology. 2016 Jun 15;361-362:24-38.