| Major Field of Research |
Neuroimmune Network Research Laboratory mainly focuses on the role of microglia, the highly dynamic immune cells in the central nervous system, in clinically relevant pathologies such as pain, glioblastoma, and neurodegenerative diseases.
The primary aim of the lab is to understand microglia-neuron communication in diseased brain. Particularly, the team investigates the molecular mechanisms underlying microglia sensing and regulation of neuronal activities. In addition, how microglia and peripheral immune cell crosstalk each other’s.
With the use of advanced genetic models along with a combination of in vivo imaging (two photon and miniscope, molecular biology techniques and awake-behavioral studies in rodent models, the team reveals microglia-specific receptors and mechanisms in microglial function. The long-term vision of the Yi lab research is to identify and manipulate microglia-specific therapeutic targets that will complement existing strategies for the treatment of brain diseases, including pain, glioblastoma, and neurodegenerative diseases. DETAIL |
