본문
Rhee, Joon Haeng
| Department | Microbiology and Immunology |
|---|---|
| Major Field of Research | Molecular Microbiology |
| jhrhee@jnu.ac.kr | |
| Homepage |
Research interests
Research Center for cancer immunotherapyOur lab focuses on the development of cellular cancer immunotherapies for the treatment of cancer, such as:
1) development of dendritic cell-based cancer immunotherapy,
2) Development of natural killer cell-based anticancer immunotherapy,
3) Development of chimeric antigen receptor (CAR) T cells and CAR NK cells against cancer,
4) Development of marrow infiltrating lymphocytes (MIL) against multiple myeloma,
Publication
- Hwang HS, Cherukula K, Bang YJ, Vijayan V, Moon MJ, Thiruppathi J, Puth S, Jeong YY, Park IK, Lee SE, Rhee JH. Combination of Photodynamic Therapy and a Flagellin-Adjuvanted Cancer Vaccine Potentiated the Anti-PD-1-Mediated Melanoma Suppression. Cells. 2020 Nov 7;9(11):E2432. doi: 10.3390/cells9112432.
- Tan W, Jeong K, Pendru R, Puth S, Hong SH, Lee SE, Rhee JH. The cytochrome d oxidase complex regulated by fexA is an Achilles' heel in the in vivo survival of Vibrio vulnificus. Emerg Microbes Infect. 2019;8(1):1406-1415. doi: 10.1080/22221751.2019.1665972.
- Duong-Nu TM, Jeong K, HongSH, Puth S, Kim SY, Tan W, Lee KH, Lee SE, Rhee JH. A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation. PLoS Pathog. 2019 Aug 22;15(8):e1007767. doi: 10.1371/journal.ppat.1007767.
- Guo RH, Im YJ, Shin SI,Jeong K, Rhee JH, Kim YR. Vibrio vulnificus RtxA1 cytotoxin targets filamin A to regulatePAK1- and MAPK-dependent cytoskeleton reorganization and cell death. Emerg Microbes Infect. 2019;8(1):934-945. doi: 10.1080/22221751.2019.1632153. (co-correspondence)
- Tan W, Zheng JH, Duong TMN, Koh YI, Lee SE, Rhee JH. A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma. Allergy Asthma Immunol Res. 2019 Mar;11(2):254-266. doi: 10.4168/aair.2019.11.2.254.
- Puth S, Hong SH, Na HS, Lee HH, Lee YS, Kim SY, Tan W, Hwang HS, Sivasamy S, Jeong K, Kook JK, Ahn SJ, Kang IC, Ryu JH, Koh JT, Rhee JH, Lee SE. A built-in adjuvant-engineered mucosal vaccine against dysbioticperiodontal diseases. Mucosal Immunol. 2019 Mar;12(2):565-579.doi: 10.1038/s41385-018-0104-6. Epub 2018 Nov 28.(co-correspondence)
- Hwang HS, Puth S, Tan W,Verma V, Jeong K, Lee SE, Rhee JH. More robust gut immune responses induced by combining intranasal and sublingual routes for prime-boost immunization. Hum Vaccin Immunother. 2018;14(9):2194-2202.doi: 10.1080/21645515.2018.1472185. Epub 2018 Jun 19.
- Puth S, Hong SH, Park MJ, Lee HH, Lee YS, Jeong K, Kang IC, Koh JT, Moon B, Park SC, Rhee JH, Lee SE. Mucosal immunization with a flagellin-adjuvanted Hgp44 vaccine enhances protective immune responses in a murine Porphyromonas gingivalis infection model. Hum Vaccin Immunother. 2017 Jun 12:0. doi: 10.1080/21645515.2017.1327109. (co-correspondence)
- Zheng JH, Nguyen VH, Jiang SN, Park SH, Tan W, Hong SH, Shin MG, Chung IJ, Hong Y, Bom HS, Choy HE, Lee SE, Rhee JH, Min JJ. Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin. Sci Transl Med. 2017 Feb 8;9(376). pii: eaak9537. doi: 10.1126/scitranslmed.aak9537. doi: 10.1126/scitranslmed.aak9537. (co-correspondence)
- Verma V, Kim Y, Lee MC, Lee JT, Cho S, Park IK, Min JJ, Lee JJ, Lee SE, Rhee JH. Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression. Oncotarget. 2016 Jun28;7(26):39894-39906. doi: 10.18632/oncotarget.9529.
- Verma V, Tan W, Puth S, Cho KO, Lee SE, Rhee JH. Norovirus (NoV) specific protective immune responses induced by recombinant P dimer vaccine are enhanced by the mucosal adjuvant FlaB. J Transl Med. 2016 May 17;14(1):135. doi: 10.1186/s12967-016-0899-4.
- Lee SE, Hong SH, Verma V, Lee YS, Duong T-MN, Jeong K, Uthaman S, Sung YC, Lee J-T, Park I-K, Min J-J, Rhee JH. Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer. Oncoimmunol. 2016 5(2), e1081328
- Duong-Nu TM, Jeong K, Hong SH, Nguyen VH, VanNgo H, Min JJ, Lee SE, Rhee JH. All three TonB systems are required for Vibrio vulnificus CMCP6 tissueinvasiveness by controlling flagellum expression. Infect Immun. 2015 Nov2;84(1):254-65. doi: 10.1128/IAI.00821-15.