본문
| Department | Physical Medicine and Rehabilitation |
|---|---|
| Major Field of Research | cardiac rehabilitation, muscuolskeletal rehabilitation, geriatric rehabilitation |
| rmhanjy@daum.net | |
| Homepage |
Research interests
Professor Jae-Young Han's laboratory is conducting research on the following subjects using genotype-mutated dementia mice as animal models. In addition, new treatment methods are being implemented by applying optimal conditions to patients with brain diseases based on the results of animal experiments.
1. Repetitive transcranial magnetic stimulation
- Although the regeneration of central nerve tissue is limited, one of the main mechanisms leading to the recovery of brain function occurs through the process of neuroplasticity. The process of neuroplasticity includes changes in neural circuits and synapses due to behavioral changes, changes caused by internal and external environments, or nerve damage.
- Repetitive transcranial magnetic stimulation rTMS is a non-invasive method of stimulating the cerebrum and can locally activate or inhibit a specific part of the brain by causing neuromodulation.
- The purpose of this study is to identify changes in neuroplasticity of the brain by stimulating rTMS in MCAo mouse, an artificial stroke model, and to secure optimal conditions based on the results and to utilize them in the rehabilitation field.
2. Transcranial direct current, alternating current electrical stimulation
- Non-invasive brain stimulation is a method of adjusting cortical activity by directly applying stimulation to a target part of the cerebral cortex.
- Transcranial direct current stimulation (tDCS) is known to affect brain activation through N-methyl-D-aspartic acid. Although the effect of tDCS lasts for several hours, it is known that it is shortened to minutes by dextromethorphan, an NMDA receptor antagonist. In addition, tDCS has been reported to have a direct effect on the gene expression of calcium ion influx and brain-derived neurotrophic factors, which play an important role in synapse formation, along with the NMDA receptor, which plays a major role in synaptic transmission and synaptic plasticity.
Transcranial alternate current stimulation (tACS) is a method of causing changes in neuroplasticity in the brain by inducing changes in wavelength bands (delta, theta, alpha, beta, gamma) that occur in the brain by applying AC stimulation to the dermis of the brain This is a study that confirms the phenomena that occur in brain lesions by applying stimulation through electrophysiological and molecular biological methods through animal experiments.
The purpose of this study is to investigate the effects of transcranial direct current and alternating current stimulation on lesions caused by cranial nerve degeneration and to secure optimal conditions for improving motor and cognitive functions by utilizing them in the rehabilitation field.
그림 stroke model 만들기 및 rTMS 실험에 따른 microarray analysis
그림 반복 경두개 자기자극 실험 및 분석
그림 경두개 직류자극 실험 및 분석, 실제 환자 적용
Publication
- 최근 5년간 대표 논문
- 1. Kim RB, Hwang JY, Park HW, Her AY, Lee JH, Kim MH, et al. Contemporary Status of Acute Myocardial Infarction in Korean Patients: Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers. J Clin Med. 2021;10(3).
- 2. Kim JH, Han JY, Park GC, Lee JS. Cognitive Improvement Effects of Electroacupuncture Combined with Computer-Based Cognitive Rehabilitation in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. Brain Sci. 2020;10(12).
- 3. Kim C, Choi I, Cho S, Han JY, Kim AR, Kim WS, et al. Cardiac rehabilitation and 5-year mortality after acute myocardial infarction. Report from 11 tertiary hospitals in Korea (ETHIK Study). Eur J Phys Rehabil Med. 2020;56(4):489-95.
- 4. Kim JH, Han JY, Song MK, Park GC, Lee JS. Synergistic Effects of Scalp Acupuncture and Repetitive Transcranial Magnetic Stimulation on Cerebral Infarction: A Randomized Controlled Pilot Trial. Brain Sci. 2020;10(2).
- 5. Kim KH, Jang YC, Song MK, Park HK, Choi IS, Han JY. Changes in Aerobic Capacity Over Time in Elderly Patients With Acute Myocardial Infarction During Cardiac Rehabilitation. Ann Rehabil Med. 2020;44(1):77-84.
- 6. Kim WI, Han JY, Song MK, Park HK, Jo J. Cognitive Function Improvement in Mouse Model of Alzheimer's Disease Following Transcranial Direct Current Stimulation. Brain Sci. 2020;10(8).
- 7. Park HK, Song MK, Kim JH, Han JY. A randomized controlled trial to evaluate the effectiveness and safety of electro acupuncture and transcranial direct current stimulation with computerized cognitive rehabilitation in patients with vascular cognitive impairment. Medicine (Baltimore). 2020;99(29):e21263.
- 8. Park HK, Song MK, Kim WI, Han JY. Regulation of gene expression after combined scalp acupuncture and transcranial magnetic stimulation in middle cerebral artery occlusion mice. Restor Neurol Neurosci. 2020;38(3):253-63.
- 9. Jang YC, Park HK, Han JY, Choi IS, Song MK. Cardiopulmonary function after robotic exoskeleton-assisted over-ground walking training of a patient with an incomplete spinal cord injury: Case report. Medicine (Baltimore). 2019;98(50):e18286.
- 10. Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jee S, et al. Clinical Practice Guideline for Cardiac Rehabilitation in Korea: Recommendations for Cardiac Rehabilitation and Secondary Prevention after Acute Coronary Syndrome. Korean Circ J. 2019;49(11):1066-111.
- 11. Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jee S, et al. Clinical Practice Guideline for Cardiac Rehabilitation in Korea. Korean J Thorac Cardiovasc Surg. 2019;52(4):248-85.
- 12. Kim JH, Han JY, Park GC, Lee JS. Effects of electroacupuncture combined with computer-based cognitive rehabilitation on mild cognitive impairment: study protocol for a pilot randomized controlled trial. Trials. 2019;20(1):478.
- 13. Kim C, Sung J, Lee JH, Kim WS, Lee GJ, Jee S, et al. Clinical Practice Guideline for Cardiac Rehabilitation in Korea. Ann Rehabil Med. 2019;43(3):355-443.
- 14. Park HK, Kim KH, Kim JH, Song MK, Choi IS, Han JY. Comparison of Obesity Related Index and Exercise Capacity Between Center-Based and Home-Based Cardiac Rehabilitation Programs. Ann Rehabil Med. 2019;43(3):297-304.
- 15. Lee JH, Choi KH, Kang S, Kim DH, Kim DH, Kim BR, et al. Nonsurgical treatments for patients with radicular pain from lumbosacral disc herniation. Spine J. 2019;19(9):1478-89.
- 16. Choe Y, Han JY, Choi IS, Park HK. Improvement of exercise capacity in patients with type 2 diabetes mellitus during cardiac rehabilitation. Eur J Phys Rehabil Med. 2018;54(6):981-3.
- 17. Choe Y, Han JY, Choi IS, Park HK. Changes in Oxygen Consumption and Heart Rate After Acute Myocardial Infarction During 6-Month Follow-up. PM R. 2018;10(6):587-93.
- 18. Kim JH, Choe YR, Song MK, Choi IS, Han JY. Relationship Between Post-exercise Heart Rate Recovery and Changing Ratio of Cardiopulmonary Exercise Capacity. Ann Rehabil Med. 2017;41(6):1039-46.
- 19. You YN, Cho MR, Kim JH, Park JH, Park GC, Song MY, et al. Assessing the quality of reports about randomized controlled trials of scalp acupuncture combined with another treatment for stroke. BMC Complement Altern Med. 2017;17(1):452.
- 20. You YN, Cho MR, Park JH, Park GC, Song MY, Choi JB, et al. Assessing the quality of reports about randomized controlled trials of scalp acupuncture treatment for vascular dementia. Trials. 2017;18(1):205.
- 21. Nguyen TT, Lian S, Ung TT, Xia Y, Han JY, Jung YD. Lithocholic Acid Stimulates IL-8 Expression in Human Colorectal Cancer Cells Via Activation of Erk1/2 MAPK and Suppression of STAT3 Activity. J Cell Biochem. 2017;118(9):2958-67.
- 22. Kim DJ, Lee KY, Choe Y, Han JY, Choi IS. Cardiac rehabilitation in an adolescent with DiGeorge Syndrome. Eur J Phys Rehabil Med. 2017;53(3):462-5.
- 23. Lim SK, Han JY, Choe YR. Comparison of the Effects of Cardiac Rehabilitation Between Obese and Non-obese Patients After Acute Myocardial Infarction. Ann Rehabil Med. 2016;40(5):924-32.
- 24. Lee KY, Han JY, Kim JH, Kim DJ, Choi IS. Physiological Responses During the Lower Body Positive Pressure Supported Treadmill Test. Ann Rehabil Med. 2016;40(5):915-23.
- 25. Lee DW, Lim CH, Han JY, Kim WM. Chronic pelvic pain arising from dysfunctional stabilizing muscles of the hip joint and pelvis. Korean J Pain. 2016;29(4):274-6.
- 26. Han JY, Kim JH, Park JH, Song MY, Song MK, Kim DJ, et al. Scalp acupuncture and electromagnetic convergence stimulation for patients with cerebral infarction: study protocol for a randomized controlled trial. Trials. 2016;17(1):490.
- 27. Lim SK, Sim DS, Han JY. The factors associated with sexual recovery in male patients with acute myocardial infarction under phase II cardiac rehabilitation. J Clin Nurs. 2016;25(19-20):2827-34.
- 28. Han JY, Kim JK, Kim JH, Oh BS, Cho WJ, Jung YD, et al. Neurorestorative effects of epigallocatechin-3-Gallate on cognitive function in a chronic cerebral hypoperfusion rat model. Restor Neurol Neurosci. 2016;34(3):367-77.