본문
Yi MH
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| Major Field of Research | Neuroimmune Network Research Laboratory mainly focuses on the role of microglia, the highly dynamic immune cells in the central nervous system, in clinically relevant pathologies such as pain, glioblastoma, and neurodegenerative diseases. The primary aim of the lab is to understand microglia-neuron communication in diseased brain. Particularly, the team investigates the molecular mechanisms underlying microglia sensing and regulation of neuronal activities. In addition, how microglia and peripheral immune cell crosstalk each other’s. With the use of advanced genetic models along with a combination of in vivo imaging (two photon and miniscope, molecular biology techniques and awake-behavioral studies in rodent models, the team reveals microglia-specific receptors and mechanisms in microglial function. The long-term vision of the Yi lab research is to identify and manipulate microglia-specific therapeutic targets that will complement existing strategies for the treatment of brain diseases, including pain, glioblastoma, and neurodegenerative diseases. |
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Research interests
Publication
- 1) Yi MH, Lee J, Moon S, So E, Bang G, Moon KS, Lee KH. Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies. Biomedicines. 2025 Jan 16;13(1):216. doi: 10.3390/biomedicines13010216.
- 2) Haruwaka K, Ying Y, Liang Y, Umpierre AD, Yi MH, Kremen V, Chen T, Xie T, Qi F, Zhao S, Zheng J, Liu YU, Dong H, Worrell GA, Wu LJ. Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses. Nat Neurosci. 2024 Jan 4. doi: 10.1038/s41593-023-01537-8. Online ahead of print. IF: 28.771 (2023).
- 3) Shin HJ, Choi SG, Qu F, Yi MH, Lee CH, Kim SR, Kim HG, Beom J, Yi Y, Kim DK, Joe EH, Song HJ, Kim Y, Kim DW. Peptide-mediated targeted delivery of SOX9 nanoparticles into astrocytes ameliorates ischemic brain injury. Nanoscale. 2023 Dec 14. doi: 10.1039/d3nr01318a. IF: 8.307 (2023).
- 4) Dheer A, Bosco DB, Zheng J, Wang L, Zhao S, Haruwaka K, Yi MH, Barath A, Tian DS, Wu LJ. Chemogenetic approaches reveal dual functions of microglia in seizures. Brain Behav Immun. 2024 Jan;115:406-418. IF: 19.227 (2023).
- 5) Gu N*, Yi MH*, Murugan M, Xie M, Parusel S, Peng J, Eyo UB, Hunt CL, Dong H, Wu LJ. Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity. Mol Brain. 2022 Oct 26;15(1):86. IF: 4.399 (2021).
- 6) Parusel S*, Yi MH*, Hunt CL, Wu LJ. Chemogenetic and optogenetic manipulations of microglia in chronic pain. Neuroscience Bull. Review. 2022 Aug 17;s12264-022-00937-3. IF: 5.271 (2021).
- 7) Peng J*, Yi MH*, Jeong H, McEwan P, Zheng J, Wu G, Ganatra S, Ren Y, Richardson J, Oh SB, Wu LJ. The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury. Mol Brain 2021 Jun 28;14(1):99. IF: 4.399 (2021).
- 8) Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biol. 2021 Mar 19;19(3):e3001154. Selected as a Research highlights in Nature Neurology Review, 2021 May;17(5):262 PMID:33828292 IF: 9.593 (2021).
- 9) Yi MH, Liu YU, Liu K, Chen T, Bosco DB, Zheng J, Xie M, Zhou L, Qu W, Wu LJ. Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice. Brain Behav Immun. 2021 Feb;92:78-89. IF: 19.227 (2021).
- 10) Park HJ, Hong J, Piao Y, Shin HJ, Lee SJ, Rhyu IJ, Yi MH, Kim J, Kim DW, Beom J. Extracorporeal shockwave therapy enhances peripheral nerve remyelination and gait function in a crush model. Adv Clin Exp Med. 2020 Jul; 29 (7):819-824. IF: 1.736 (2021).
- 11) Chen T, Lennon VA, Liu YU, Bosco DB, Li Y, Yi MH, Zhu J, Wei S, Wu LJ. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. J Clin Invest. 2020 Aug 3; 130 (8): 4025-4038. IF: 19.477 (2021).
- 12) Pandit S, Neupane C, Woo J, Sharma R, Nam MH, Lee GS, Yi MH, Shin N, Kim DW, Cho H, Jeon BH, Kim HW, Lee CJ, Park JB. Bestrophin1-mediated tonic GABA release from reactive astrocytes prevents the development of seizure-prone network in kainate-injected hippocampi. Glia. 2020 May; 68 (5):1065-1080. IF: 8.073 (2021).