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| Department | |
|---|---|
| Major Field of Research | Our research investigates the biological mechanisms of aging and aims to develop innovative therapeutic strategies that delay aging, enhance immune function, and restore tissue homeostasis. We focus on cellular senescence, immune and metabolic aging, rejuvenation strategies, and therapeutic model development to address aging-related dysfunctions and diseases. |
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Research interests
Cellular Senescence
Aging is
driven by the accumulation of senescent cells, which contribute to chronic
inflammation and tissue dysfunction. We study the molecular mechanisms
underlying senescence-associated secretory phenotype (SASP) and
explore strategies to eliminate or reprogram senescent cells to
restore tissue integrity and delay aging-related diseases.
Systemic Aging – Immune and Metabolic
Dysregulation
Aging
leads to immune system decline (immunosenescence) and chronic
inflammation (inflammaging), which accelerate disease onset. We focus
on TLR5 signaling as a key modulator of immune aging, studying its
role in mucosal immunity and systemic health. Additionally, we
investigate age-related metabolic disorders using TLR5 knockout
models, exploring the interplay between immune dysfunction and metabolic
decline.
Rejuvenation and Functional Recovery
Aging-related
dysfunctions can be reversed through immune modulation, metabolic
reprogramming, and tissue regeneration. We develop functional rejuvenation
strategies targeting immune and metabolic pathways to restore
physiological function and promote longevity.
Therapeutic Model Development
Our research translates fundamental discoveries into therapeutic applications by developing immune-stimulating interventions, metabolic regulators, and anti-aging drug candidates. We utilize preclinical models, and multi-omics approaches to identify biomarkers of aging and evaluate novel interventions for clinical translation.
Publication
- Nguyen TQ and Cho KA, Targeting Immunosenescence and Inflammaging: Advancing Longevity Research. (Invited review). Under review in Exp Mol Med. 2025
- Kim DH, et al., The Impact of TLR5 on Liver Function in Age-Related Metabolic Disorders. Accepted in Aging Cell. 2025
- Lim JS, et al., Mucosal TLR5 activation controls healthspan and longevity. Nature Communications. 2024 Jan;15:46.
- Park SC, et al., What matters in aging is signaling for responsiveness. Pharmacology & Therapeutics. 2023 252:108560
- Lim JS, et al., Piperine: an anticancer and senostatic drug. Frontiers in Bioscience. 2022 Apr 20;27(4):137.
- Park JH, et al., Disruption of nucleocytoplasmic trafficking as a cellular senescence driver. Exp Mol Med. 2021 Jun;53(6):1092-1108
- Jo D, et al., The Cerebral Effect of Ammonia in Brain Aging: Blood-Brain Barrier Breakdown, Mitochondrial Dysfunction, and Neuroinflammation. J Clin Med. 2021 Jun 24;10(13):2773
- Lim JS, et al., Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype. Mech Ageing Dev. 2020 Dec;192:111355.
- Kim SY, et al., Global transcriptional downregulation of TREX and nuclear trafficking machinery as pan-senescence phenomena: evidence from human cells and tissues. Exp Mol Med. 2020 Aug;52(8):1351-1359.
- Lee YR, et al., Metabolite Profiling of Rambutan (Nephelium lappaceum L.) Seeds Using UPLC-qTOF-MS/MS and Senomorphic Effects in Aged Human Dermal Fibroblasts. Nutrients. 2020 May 15;12(5):1430.
- Kuk MU, et al., Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. Mol Cells. 2019 Mar31;42(3):210-217.
- Yoon G, et al., Transcriptomic Analysis of High Fat Diet Fed Mouse Brain Cortex. Front Genet. 2019 Feb 19;10:83.
- Sueoka E, et al., Meeting report of the 14th Japan-Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine. J Cancer Res Clin Oncol. 2019 May;145(5):1263-1271.