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연구 세계적 의생명과학 연구를 선도하는 연구자 양성

교수진 세계적 의생명과학 연구를 선도하는 연구자 양성

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교수진

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김낙성
교실(과) 약리학
연구(전공)분야 조골세포와 파골세포 내 유전자 조절, 골세포내 세포신호 연구, 골면역학
이메일 nacksung@jnu.ac.kr
홈페이지

학력

  • 1985. 서울대학교 자연대학 미생물학과 졸업(이학사)
  • 1987. 서울대학교 대학원 미생물학과(이학석사)
  • 1995. 서울대학교 대학원 미생물학과(이학박사)

경력 및 해외 연수

  • 1996 – 1998 : Division of Allergy and Immunology, University of Tennessee(ResearchFellow)
  • 1998 – 2001 : Laboratory of Immunology, RockefellerUniversity(ResearchFellow)
  • 2001 – 2002 : Department of Pathology and Laboratory Medicine, University of PennsylvaniaSchoolofMedicine(ResearchFellow)
  • 2002 – 2004 : Department of Pathology and Laboratory Medicine, University of PennsylvaniaSchoolofMedicine(ResearchAssistantProfessor)

연구소개

 

연구업적 및 저서

  • 1. Youn BU, Kim K, Kim JH, Lee J, Moon JB, Kim I, Park YW, Kim N. SLAT negatively regulates RANKL-induced osteoclast differentiation. Mol Cells. 2013 Sep;36(3):252-7.
  • 2. Lee OJ, Cho YN, Kee SJ, Kim MJ, Jin HM, Lee SJ, Park KJ, Kim TJ, Lee SS, Kwon YS, Kim N, Shin MG, Shin JH, Suh SP, Ryang DW, Park YW. Circulating mucosal-associated invariant T cell levels and their cytokine levels in healthy adults. Exp Gerontol. 2014 Jan;49:47-54.
  • 3. Song I, Kim K, Kim JH, Lee YK, Jung HJ, Byun HO, Yoon G, Kim N. GATA4 negatively regulates osteoblast differentiation by downregulation of Runx2. BMB Rep. 2014 Aug;47(8):463-8.
  • 4. Hong YJ, Cho YN, Kim TJ, Jin HM, Kim MJ, Jung HJ, Kang JH, Lee SJ, Park KJ, Kim N, Kee SJ, Park YW. Functional deficiency of natural killer cells in acute coronary syndrome is related to ineffective degranulation. Int J Cardiol. 2014 Apr 1;172(3):613-5.
  • 5. Kim JH, Kim K, Youn BU, Lee J, Kim I, Shin HI, Akiyama H, Choi Y, Kim N. Kruppel-like factor 4 attenuates osteoblast formation, function, and cross talk with osteoclasts. J Cell Biol. 2014 Mar 17;204(6):1063-74.
  • 6. Cho YN, Kee SJ, Kim TJ, Jin HM, Kim MJ, Jung HJ, Park KJ, Lee SJ, Lee SS, Kwon YS, Kee HJ, Kim N, Park YW. Mucosal-associated invariant T cell deficiency in systemic lupus erythematosus. J Immunol. 2014 Oct 15;193(8):3891-901.
  • 7. Kim JH, Youn BU, Kim K, Moon JB, Lee J, Nam KI, Park YW, O'Leary DD, Kim KK, Kim N. Lhx2 regulates bone remodeling in mice by modulating RANKL signaling in osteoclasts. Cell Death Differ. 2014 Oct;21(10):1613-21.
  • 8. Kim JH, Kim N. Regulation of NFATc1 in Osteoclast Differentiation. J Bone Metab. 2014 Nov;21(4):233-41.
  • 9. Kim K, Kim JH, Kim I, Lee J, Seong S, Park YW, Kim N. MicroRNA-26a regulates RANKL-induced osteoclast formation. Mol Cells. 2015 Jan 31;38(1):75-80.
  • 10. Kwon YS, Cho YN, Kim MJ, Jin HM, Jung HJ, Kang JH, Park KJ, Kim TJ, Kee HJ, Kim N, Kee SJ, Park YW. Mucosal-associated invariant T cells are numerically and functionally deficient in patients with mycobacterial infection and reflect disease activity. Tuberculosis (Edinb). 2015 May;95(3):267-74.
  • 11. Lee J, Youn BU, Kim K, Kim JH, Lee DH, Seong S, Kim I, Han SH, Che X, Choi JY, Park YW, Kook H, Kim KK, Lim DS, Kim N. Mst2 Controls Bone Homeostasis by Regulating Osteoclast and Osteoblast Differentiation. J Bone Miner Res. 2015 Sep;30(9):1597-607.
  • 12. Kwon HJ, Kwon SJ, Lee H, Park HR, Choi GE, Kang SW, Kwon SW, Kim N, Lee SY, Ryu S, Kim SC, Kim HS. NK cell function triggered by multiple activating receptors is negatively regulated by glycogen synthase kinase-3β. Cell Signal. 2015 Sep;27(9):1731-41.
  • 13. Yang JM, Choi W, Kim N, Yoon KC. Comparison of Topical Cyclosporine and Diquafosol Treatment in Dry Eye. Optom Vis Sci. 2015 Sep;92(9):e296-302.
  • 14. Jin HM, Kee SJ, Cho YN, Kang JH, Kim MJ, Jung HJ, Park KJ, Kim TJ, Lee SI, Choi H, Koh JT, Kim N, Park YW. Dysregulated Osteoclastogenesis Is Related to Natural Killer T Cell Dysfunction in Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Oct;67(10):2639-50.
  • 15. Kim JH, Kim K, Kim I, Seong S, Kim N. NRROS Negatively Regulates Osteoclast Differentiation by Inhibiting RANKL-Mediated NF-κB and Reactive Oxygen Species Pathways. Mol Cells. 2015 Oct 31;38(10):904-10.
  • 16. Kim JH, Kim K, Kim I, Seong S, Nam KI, Lee SH, Kim KK, Kim N. Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function. J Immunol. 2016 Feb 1;196(3):1123-31.
  • 17. Kwon DH, Eom GH, Ko JH, Shin S, Joung H, Choe N, Nam YS, Min HK, Kook T, Yoon S, Kang W, Kim YS, Kim HS, Choi H, Koh JT, Kim N, Ahn Y, Cho HJ, Lee IK, Park DH, Suk K, Seo SB, Wissing ER, Mendrysa SM, Nam KI, Kook H. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun. 2016 Feb 1;7:10492.
  • 18. Kim JH, Kim N. Signaling Pathways in Osteoclast Differentiation. Chonnam Med J. 2016 Jan;52(1):12-7.
  • 19. Hur J, Ghosh A, Kim K, Ta HM, Kim H, Kim N, Hwang HY, Kim KK. Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKLBinding Affinity. Mol Cells. 2016 Apr 30;39(4):316-21.
  • 20. Song I, Jeong BC, Choi YJ, Chung YS, Kim N. GATA4 negatively regulates bone sialoprotein expression in osteoblasts. BMB Rep. 2016 Jun;49(6):343-8.
  • 21. Kim JH, Seong S, Kim K, Kim I, Jeong BC, Kim N. Downregulation of Runx2 by 1,25-Dihydroxyvitamin D₃ Induces the Transdifferentiation of Osteoblasts to Adipocytes. Int J Mol Sci. 2016 May 19;17(5).
  • 22. Lee J, Seong S, Kim JH, Kim K, Kim I, Jeong BC, Nam KI, Kim KK, Hennighausen L, Kim N. STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis. Sci Rep. 2016 Aug 3;6:30977.

학회활동

  • 2008~2010 대한골다공증학회 / 학술위원
  • 2009~2013 대한골대사학회 / 학술이사
  • 2013~2015 대한골대사학회 / 연구이사
  • 2015~2016 대한골대사학회 / 부회장
  • 2016 대한골대사학회 / 평의원