본문
| 교실(과) | 마취통증의학 |
|---|---|
| 연구(전공)분야 | 만성통증 |
| 이메일 | kimwm@jnu.ac.kr |
| 홈페이지 |
학력
- 1999. 전남대학교 의과대학 졸업 (의학사)
- 2002. 전남대학교 대학원 의학과 (의학석사)
- 2011. 전남대학교 대학원 의학과 (의학박사)
경력 및 해외 연수
- 2004. 04. 마취통증의학과 전문의 취득
- 2007. 05. ~ 2008. 02. 전남대학교병원 마취통증의학과 전임의
- 2008. 03. ~ 2009. 02. 전남대학교병원 마취통증의학과 임상전임강사
- 2009. 03. ~ 2011. 02. 전남대학교병원 마취통증의학과 임상조교수
- 2011. 02. ~ 현재 전남대학교 의과대학 기금조교수
연구소개
Animal models of pain
To investigate pain transmission, identify new targets for pain relief, and characterize the potential analgesic profile of novel compounds , we are using an array of experimental animal pain models mainly of rats, reflecting all types of pain, from acute to chronic and nociceptive to neuropathic and cancer-related pain. Depending on the model, modalities for pain measurements encompass spontaneous pain behaviors as well as evoked pain by various techniques.
Animal models of nociception: Formalin/Carrageenan model, Paw incision model, Post-surgical pain model, Spinal nerve ligation model, Bone cancer pain model, Chemotherapy-induced peripheral neuropathy model, Morphine tolerance model, Chronic post-ischemia pain model.
Behavioral assessment: Hot/cold plate, Hot box, von Frey monofilaments test.
2. Pharmacologic intervention
To study central nervous system mechanisms of pain or action of target compound, we are utilizing intracranial or spinal routes of administration (Fig. 1) as well as systemic delivery of experimental compounds, thus activating or inactivating specific proteins that reside in spinal cord or brain and also enabling the microdialysis analyses of extracellular environmental change.
3. Microdialysis study
In addition to the immunoassay or immunostaining techniques which show the abundance, distribution, and localization of target protein, we analyze samples obtained from microdialysis experiments in the spinal cord or brain (Fig. 2). Microdialysis study enables the analysis of the change in extracellular environment where the neurotransmitters are released to act on their relevant receptors. Compared to other techniques such as the measurements or total content of specific protein in the tissue, this analysis may provide more information about the activity of specific pathway of pain transmission of modulation.
연구업적 및 저서
- 1. Antinociceptive effect of intrathecal nefopam and interaction with morphine in formalin-induced pain of rats. Korean J Pain 2013; 26(1): 14-20.
- 2. The Intrathecally Administered Kappa-2 Opioid Agonist GR89696 and Interleukin-10 Attenuate Bone Cancer？Induced Pain Through Synergistic Interaction. Anesthesia & Analgesia 2012; 113(4): 683-9.
- 3. Cardiovascular and arousal responses to single-lumen endotracheal and double-lumen endobronchial intubation in the normotensive and hypertensive elderly. Korean J Anesthesiol 2011; 60(2): 90-7.
- 4. Roles of Adenosine and Serotonin Receptors on the Antinociception of Sildenafil in the Spinal Cord of Rats. Yonsei Med J 2010;51(6):960-4.
- 5. Antiallodynic Effect of Thalidomide and Morphine on Rat Spinal Nerve Ligation-induced
- Korean J Pain 2010; 23(3): 172-8.
- (그외 다수)
학회활동
- 대한마취과학회 정회원
- 대한통증학회 정회원
- 대한척추통증연구회 정회원
- 대한통증연구학회 정회원