본문
이시은
| 교실(과) | 치과약리학 |
|---|---|
| 연구(전공)분야 | Vaccine, Immunotherapy, Adjuvant, Host-microbe biointerface |
| 이메일 | selee@chonnam.ac.kr |
| 홈페이지 | dent.jnu.ac.kr/user/indexMain.action?siteId=dent |
연구소개
1. 백신 연구 개발
- 백신 면역증강제 원천기술 확립: 예> 작용 기전 규명, 응용법 개발, 과학적 근거 확립, 실용화 추구 연구 진행
- 백신 면역증강제 (druggable vaccine adjuvant) 개발 (예> deimmunized flagellin, 다기능성 면역증강제 개발)
- 빌트인 면역증강제를 포함하는 백신 제제 개발
- 다양한 감염 질환 예방에 적용할 수 있는 점막 백신 개발
- Dysbiotic 질환을 조절할 수 있는 신개념 백신 개발
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2. 면역치료법
- 원천기술을 활용한 다양한 면역치료법 개발: 예> 암, 알레르기 등
- 단백질/펩타이드-기반 항암 치료 백신 개발
3. 분자미생물 병인론 연구
- 숙주-미생물 상호작용 (host-microbe interaction)의 이해에 기반을 둔 병인론 연구
- 생체 감염 시 발현되는 유전자군이 미생물 병인론에 미치는 작용 기전 연구
Figure 1. Development of TLR-targeting vaccine adjuvant and its application in cancer immunotherapy
Figure 2. A built-in adjuvant-engineered mucosal vaccine against dysbiotic periodontal diseases
연구업적 및 저서
- Hwang HS, Cherukula K, Bang YJ, Vijayan V, Moon MJ, Thiruppathi J, Puth S, Jeong YY, Park I-K*, Lee SE*, Rhee JH*. Combination of photodynamic therapy and a flagellin-adjuvanted cancer vaccine potentiated the anti-PD-1-mediated melanoma suppression. Cells. 2020 Nov 7; 9(11): E2432. * co-corresponding authors
- Duong-Nu T-M, Jeong K, Hong SH, Puth S, Kim SY, Tan W, Lee KH, Lee SE*, Rhee JH*. A stealth adhesion factor contributes to Vibrio vulnificus pathogenicity: Flp pili play roles in host invasion, survival in the blood stream and resistance to complement activation. PLoS Pathogens 2019 Aug 22;15(8):e1007767. * co-corresponding authors
- Tan W, Jeong K, Pendru R, Puth S, Hong SH, Lee SE*, Rhee JH*. The cytochrome d oxidase complex regulated by FexA is an Achilles’ heel in the in vivo survival of Vibrio vulnificus. Emerging Microbes and Infections 2019 8(1) 1406-1415. * co-corresponding authors
- Puth S, Hong SH, Na HS, Lee HH, Lee YS, Kim SY, Tan W, Hwang HS, Sivasamy S, Jeong K, Kook JK, Ahn SJ, Kang IC, Ryu JH, Koh JT, Rhee JH*, Lee SE*. A built-in adjuvant-engineered mucosal vaccine against dysbiotic periodontal diseases. Mucosal Immunology 2019 Mar; 12(2):565–579. * co-corresponding authors
- Tan W, Zheng JH, Duong-N TM, Koh Y-I, Lee SE*, Rhee JH*. A fusion protein of Derp2 allergen and flagellin suppresses experimental allergic asthma. Allergy, Asthma & Immunology Research 2019 Mar;11(2):254-266. * co-corresponding authors
- Puth S, Hong SH, Park MJ, Lee HH, Lee YS, Jeong K, Kang IC, Koh JT, Moon B, Park SC, Rhee JH*, Lee SE*. Mucosal immunization with a flagellin-adjuvanted Hgp44 vaccine enhances protective immune responses in a murine Porphyromonas gingivalis infection model. Human Vaccines & Immunotherapeutics 2017 Dec. 02; 2813(12) 2794-2803. * co-corresponding authors
- Lee SE*, Hong SH, Verma V, Lee YS, Duong NT M, Jeong K, Uthaman S, Sung YC, Lee JT, Park IK, Min JJ, Rhee JH*. Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer. OncoImmunology 2016 Feb. 5(2) e1081328 (12 pages) * co-corresponding authors
- Shim JU#, Lee SE#, Hwang W#, Lee CH, Park JW, Sohn JH, Nam JH, Kim Y, Rhee JH*, Im SH*, Koh YI*. Flagellin suppresses experimental asthma by generating regulatory dendritic cells and T cells. Journal of Allergy and Clinical Immunology 2016 Feb. 137(2) 426-435. (#equally contributed).
- Duong-N TM, Jeong K, Hong SH, Ngo V H, Lee SE*, Rhee JH*. All three TonB systems are required for Vibrio vulnificus tissue invasiveness by controlling flagellum expression. Infection and Immunity 2016 Jan. 84(1) 254-265. * co-corresponding authors