본문
이태훈
| 교실(과) | 구강생화학 |
|---|---|
| 연구(전공)분야 | 근골격계 항상성 연구 |
| 이메일 | thlee83@jnu.ac.kr |
| 홈페이지 |
연구소개
이태훈 교수 실험실은 형질전환 및 질환유도 마우스모델로 사용하여 아래와 같은 주제의 연구를 수행하고 있다. 특히 근골격계 질환에 관여하는 생체 내 단백질의 기능 규명 및 조절 약물스크린을 수행하고 있다.
1. 염증성 자극에 대한 세포의 반응 연구.
노인들은 통풍, 관절염 및 골다공증과 같은 파괴성 질환(destructive disease)의 발병율이 높고, 이는 여러 가지 감염 및 스트레스에 기이한 염증 반응을 기반으로 하고 있다. 관련된 표적 분자의 스크리닝 및 발굴을 진행하고, human primary cells 및 마우스 모델을 사용하여 염증 신호를 매개하는 단백질의 기능을 규명하는데 연구의 중점을 두고 있다. 또한 인간 염증성 질환 억제제로 이용 가능한 천연 화합물 또는 합성 화학 물질의 작용점 및 특성을 연구하고 있다.
2. 세포 신호 전달에서 항산화 효소의 기능 연구.
염증성 뼈 질환(inflammatory bone disease)과 근위축증(muscle atrophy)모델에서 산화-환원 균형( redox balance)을 연구하고 있다. 환자의 병인 기간동안 활성산소종 (ROS)의 생성을 유발하는 요인은 아직 규명되지 않았고, 질환별 특이적인 활성산소종 역시 규명되어 있지 않아 산화-환원 균형을 이해하기 위한 연구를 지속적으로 수행 중에 있다. 특히 산화스트레스와 항산화제가 골관절염 및 근육 위축과 같은 이상을 가속화하는 데 어떻게 기여하는지 연구하고 있다.
연구업적 및 저서
- Chen Z, Cho E, Ding M, Seong J, Che X, Lee S, Park BJ, Choi JY, Lee TH. N-[2-(4-benzoyl-1-piperazinyl)phenyl]-2-(4-chlorophenoxy) acetamide is a novel inhibitor of resorptive bone loss in mice. J Cell Mol Med. 2021 Feb;25(3):1425-1438.
- Eunjin Cho, Zhihao Chen, Mina Ding, Jihyoun Seong, Sunwoo Lee, Sang Hyun Min, Dong Kyu Choi, Tae-Hoon Lee. PMSA prevents osteoclastogenesis and estrogen-dependent bone loss in mice. Bone 2021 Jan 1;1(1):115707.
- Jinkyung Lee, Sun-Hee Ahn, Zhihao Chen, Sohi Kang, Dong Kyu Choi, Changjong Moon, Sang Hyun Min, Byung-Ju Park, and Tae-Hoon Lee. N-[2-(4-Acetyl-1-Piperazinyl)Phenyl]-2-(3-Methylphenoxy)Acetamide (NAPMA) Inhibits Osteoclast Differentiation and Protects against Ovariectomy-Induced Osteoporosis. Molecules. 2020 Oct 21;25(20):4855.
- Jihyoun Seong, Jinkyung Lee, Yun Kyong Lim, Weon-Jong Yoon, Seunggon Jung, Joong-Ki Kook and Tae-Hoon Lee. Osmunda japonica Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria. Int. J. Mol. Sci. 2020 Apr 1;21(7):2453.
- Jovana Baković, Bess Yi Kun Yu, Daniel Silva, Sew Peak Chew, Sangeun Kim, Sun‑Hee Ahn, Laura Palmer, Lujain Aloum, Giacomo Stanzani, Oksana Malanchuk, Michael R. Duchen, Mervyn Singer, Valeriy Filonenko, Tae-Hoon Lee, Mark Skehel, Ivan Gout. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Molecular and Cellular Biochemistry 2019 Nov; 461:91–102.
- Chen Z, Cho E, Lee J, Lee S, Lee TH. Inhibitory Effects of N-[2-(4-acetyl-1-piperazinyl) phenyl]-2-(2-chlorophenoxy) acetamide on Osteoclast Differentiation In Vitro via the Downregulation of TRAF6. Int J Mol Sci. 2019 Oct 20;20(20). pii: E5196.
- Cho E, Chen Z, Lee J, Lee S, Lee TH. PSTP-3,5-Me Inhibits Osteoclast Differentiation and Bone Resorption. Molecules. 2019 Sep 14;24(18). pii: E3346.
- Choi HI, Kim DH, Park JS, Kim IJ, Kim CS, Bae EH, Ma SK, Lee TH, Kim SW. Peroxiredoxin V (PrdxV) negatively regulates EGFR/Stat3-mediated fibrogenesis via a Cys48-dependent interaction between PrdxV and Stat3. Sci Rep. 2019 Jun 19;9(1):8751.
- Ahn SH, Chen Z, Lee J, Lee SW, Min SH, Kim ND, Lee TH. Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)-N-1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression. Molecules. 2018 Nov 29;23(12): E3139.
- Cho E, Lee JK, Lee JY, Chen Z, Ahn SH, Kim ND, Kook MS, Min SH, Park BJ, Lee TH. BCPA {N,N'-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1. Int J Mol Sci. 2018 Nov; 19(11): E3436.
- In-Gyeong Yun, Sun-Hee Ahn, Weon-Jong Yoon, Chang Sook Kim, Yun Kyong Lim, Joong-Ki Kook, Seunggon Jung, Choong-Ho Choi and Tae-Hoon Lee. Litsea japonica Leaf Extract Suppresses Proinflammatory Cytokine Production in Periodontal Ligament Fibroblasts Stimulated with Oral Pathogenic Bacteria or Interleukin-1β. Int. J. Mol. Sci. 2018, 19(9): E2494.
- Sun-Hee Ahn, Jin-Kyung Lee, Nam Doo Kim, Seok-Ho Kim, Sunwoo Lee, Seunggon Jung, Kee-Oh Chay and Tae-Hoon Lee. DPIE [2-(1,2-diphenyl-1H-indol-3-yl)ethanamine] Augments Pro-Inflammatory Cytokine Production in IL-1β-Stimulated Primary Human Oral Cells. Int. J. Mol. Sci. 2018, 19(7): E1835.
- Juhwan Kim, Sueun Lee, Sohi Kang, Tae-Il Jeon, Man-Jong Kang, Tae-Hoon Lee, Yong Sik Kim, Key-Sun Kim, Heh-In Im, and Changjong Moon. Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain. Mol. Cells 2018; 41(5): 454-464.
- Ahn SH, Chun SM, Park C, Lee JH, Lee SW, Lee TH. Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection. PLoS One. 2017 Nov 30;12(11):e0188755.
- Kim S, Ahn SH, Yang HY, Lee JS, Choi HG, Park YK, Lee TH. Modification of cysteine 457 in plakoglobin modulates the proliferation and migration of colorectal cancer cells by altering binding to E-cadherin/catenins. Redox Rep. 2017 Nov;22(6):272-281.
- S.H. Ahn, S.-H. Cho, J.-E. Song, S. Kim, S.S. Oh, S. Jung, K.A. Cho and T.-H. Lee. Caveolin-1 serves as a negative effector in senescent human gingival fibroblasts during infection. Molecular Oral Microbiology.2017June;32(3):236–249.
- Nuoc TN, Kim S, Ahn SH, Lee JS, Park BJ, Lee TH. The analysis of antioxidant expression during muscle atrophy induced by hindlimb suspension in mice. J Physiol Sci. 2017 Jan;67(1):121-129.
- Ahn SH, Song JE, Kim S, Cho SH, Lim YK, Kook JK, Kook MS, Lee TH. NOX1/2 activation in human gingival fibroblasts by Fusobacterium nucleatum facilitates attachment of Porphyromonas gingivalis. Arch Microbiol. 2016 Aug;198(6):573-83.
- Kim S, Ahn SH, Lee JS, Song JE, Cho SH, Jung S, Kim SK, Kim SH, Lee KP, Kwon KS, Lee TH. Differential Matrix Metalloprotease (MMP) Expression Profiles Found in Aged Gingiva. PLoS One. 2016 Jul 8;11(7):e0158777.