본문
스탄 라즈반
| 교실(과) | 의생명학 |
|---|---|
| 연구(전공)분야 | Immunology |
| 이메일 | strazvan@jnu.ac.kr |
| 홈페이지 |
연구소개
1) structural changes in the epitopes and paratopes from immune complexes under fever or inflammation conditions.2) mechanisms underlying transient molecular memory events in proteins, following repeated stimulations.
연구업적 및 저서
- 1. Singh PK, Choi SM, Chung IJ, Jung SI, Stan RC. Fever exerts opposing effects on the binding affinities of two neutralizing monoclonal antibodies against Staphylococcal Enterotoxin B. J Therm Biol. 2025;129:104112. doi: 10.1016/j.jtherbio.2025.104112.
- 2. Karbalaeimahdi M, Singh PK, Stan RC. Temperature promotes Fab-arm exchange in Pembrolizumab. Int J Biol Macromol. 2025;321(Pt 4):146556. doi: 10.1016/j.ijbiomac.2025.146556.
- 3. Singh PK, Stan RC. Hypothermia Exposes Hidden Epitopes in Influenza A Hemagglutinin and Potentiates the Binding of Neutralizing Antibodies. ChemSelect. 2024 Dec; 9(45): e202402618. doi:10.1002/slct.202402618.
- 4. Singh PK, Stan RC. Self-inhibition of HER2 and HER3 at fever temperatures may prevent their hetero-dimerization. J Biomol Struct Dyn. 2024 Jul;42(10):5470-5473. doi: 10.1080/07391102.2023.2227700.
- 5. Singh PK, Stan RC. ThermoPCD: a database of molecular dynamics trajectories of antibody-antigen complexes at physiologic and fever-range temperatures. Database (Oxford). 2024 Mar 19;2024:baae015. doi: 10.1093/database/baae015..
- 6. Stan RC. Higher body temperatures associated with immunotherapy may affect the activity of therapeutic antibodies. Rev Med Virol. 2024 Jan;34(1):e2516. doi: 10.1002/rmv.2516.
- 7. Singh PK, Stan RC. Enhanced binding at fever temperatures of HER2 in complex with trastuzumab and pertuzumab. Immunotherapy. 2023 Sep;15(13):1021-1027. doi: 10.2217/imt-2023-0065.
- 8. Singh PK, Stan RC. Febrile temperatures modulate the formation of immune complexes relevant for autoimmune diseases. J Therm Biol. 2023 Jan;111:103425. doi: 10.1016/j.jtherbio.2022.103425.
- 9. Stan RC. Fever range thermal therapy in sepsis. Am J Med Sci. 2023 Jun;365(6):547-549. doi: 10.1016/j.amjms.2023.03.017.
- 10. Tofan V, Lenghel A, de Camargo MM, Stan RC. Fever as an evolutionary agent to select immune complexes interfaces. Immunogenetics. 2022 Oct;74(5):465-474. doi: 10.1007/s00251-022-01263-8. 11. Palela M, Giol ED, Amzuta A, Ologu OG, Stan RC. Fever temperatures impair hemolysis caused by strains of Escherichia coli and Staphylococcus aureus. Heliyon. 2022 Feb 15;8(2):e08958. doi: 10.1016/j.heliyon.2022.e08958.
- 12. Stan RC. Temporal Modulation of Drug Desensitization Procedures. Curr Issues Mol Biol. 2022 Feb 8;44(2):833-844. doi: 10.3390/cimb44020057.