본문
장수정
| 교실(과) | 생리학 |
|---|---|
| 연구(전공)분야 | 줄기세포학, 신경생리학, 분자생물학 |
| 이메일 | sujeong.jjang@gmail.com |
| 홈페이지 | http://medicine.jnu.ac.kr/xprofessor/index.php?mode=view&number=305&smode=1&div1=1&div2=4&div3=0 |
학력
- 2003. 전남대학교 응용생물공학부 유전공학전공 (학사)
- 2005. 전남대학교 대학원 생명공학과 (석사)
- 2009. 전남대학교 대학원 분자의과학협동과정 (박사)
경력 및 해외 연수
- 2011~2012 미국 오하이오주립대학 박사후연구원
- 2013~2014 전남대학교 의과대학 조교
- 2015~2016 전남대학교 의과대학 박사후연구원
- 2017~2018 전남대학교 의과대학 리서치펠로우
- 2018.9~ 현재 전남대학교 의과대학 조교수
연구소개
Stem Cells and Regenerative Medicine Laboratory (SCRM Lab)
My research interests are; how we can develop the technique of stem cell differentiation; what are the mechanisms of neurogenic differentiation in human mesenchymal stem cells. And finally, we want to find out the therapeutic effects of transplantation on neurological disorders such as Alzheimer’s disease, Parkinson’s disease, hearing impairment, ischemic spinal cord injury, etc. We tried to regenerate the inner ear cells from animal models and recover the hearing ability. In addition, we focused on the Wnt signaling in mesenchymal stem cells after neurogenic differentiation and figured out that Wnt signaling plays a key role in controlling stem cell fate, including differentiation. Recently, we study the diverse mechanisms of stem cell exosome in Parkinson’s disease in vitro such as apoptosis, ER stress, and autophagy.
수상경력
- adipose tissue-derived stem cells using bFGF and forskolin. BMC Cell Biology 11:25.
- 12. Jang S*, Cho HH*, Lee SC, Jeong HS, Park JS, Han JY, Lee KH, Cho YB (2010) Effect of neural-induced mesenchymal stem cells and platelet-rich plasma on facial nerve regeneration in an acute nerve injury model. The Laryngoscope 120(52):907-913. *Equally contributed.
- 13. Jang S, Jeong HS, Park JS, Kim YS, Jin CY, Seol MB, Kim BC, Lee MC (2010) Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Research 1313:25-33.
연구업적 및 저서
- 1. Ramalingam M, Jeong HS, Hwang J, Cho HH, Kim BC, Kim E, Jang S* (2022 ) Autophagy Signaling by Neural-Induced Human Adipose Tissue-Derived Stem Cell-Conditioned Medium during Rotenone-Induced Toxicity in SH-SY5Y Cells. Int J Mol Sci. Apr 10;23(8):4193. doi: 10.3390/ijms23084193. *Corresponding author
- 2. Soni KK, Jeong HS, Jang S* (2022) Neurons for Ejaculation and Factors Affecting Ejaculation. Biology (Basel). Apr 29;11(5):686. doi: 10.3390/biology11050686. *Corresponding author
- 3. Ramalingam M*, Jang S*, Jeong HS* (2021) Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells. Int J Mol Sci. Feb 26;22(5):2322. doi: 10.3390/ijms22052322. *Corresponding authors
- 4. Ramalingam M*, Jang S*, Jeong HS* (2021) Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis. Stem Cells Int. Jan 22;2021:6658271. *Corresponding authors
- 5. Jang S* and Jeong HS* (2018) Data for the effect of histone deacetylase inhibitors on voltage- and ligand-gated ion channel gene expression in neurogenic induced-human adipose tissue-derived mesenchymal stem cells. Data in Brief 17:1314-19. *Corresponding authors
- 6. Jang S* and Jeong HS* (2018) Histone deacetylase inhibition-mediated neuronal differentiation via the Wnt signaling pathway in human adipose tissue-derived mesenchymal stem cells. Neuroscience Letters Jan 4;668:24-30. *Corresponding authors
- 7. Jang S, Cho HH, Park JS, Jeong HS (2017) Non-canonical Wnt mediated neurogenic differentiation of human bone marrow-derived mesenchymal stem cells. Neuroscience Letters Nov 1;660:68-73.
- 8. Jang S*, Cho HH, Kim SH, LEE KH, Cho YB, Park JS, Jeong HS* (2016) Transplantation of human adipose tissue-derived stem cells for repair of injured spiral ganglion neurons in deaf guinea pigs. Neural Regeneration Research 11(6):994-1000. *Corresponding authors
- 9. Jang S, Park JS, Jeong HS (2015) Neural differentiation of human adipose tissue-derived stem cells involves activation of the Wnt5a/JNK signalling. Stem Cells International 178618.
- 10. Jang S*, Cho HH*, Kim SH, Lee KH, Jun JY, Park JS, Jeong HS, Cho YB (2015) Neural-induced human mesenchymal stem cells promote cochlear cell regeneration in deaf guinea pigs. Clinical and Experimental Otorhinolaryngology 8(2):1-9. *Equally contributed.
- 11. Jang S, Cho HH, Cho YB, Park JS, Jeong HS (2010) Functional neural differentiation of human
학회활동
- Society for Neuroscience
- International Society for Stem Cell Research
- Korean Society for Molecular and Cellular Biology
- Korean Society for Biochemistry and Molecular Biology
- Korean Physiological Society