본문
| Department | Biochemistry |
|---|---|
| Major Field of Research | Non-coding RNA |
| ykk@jnu.ac.kr | |
| Homepage | ykkim.org |
Research interests
Professor Kim's laboratory is conducting research on non-coding RNA in various diseases and experimental models. Non-coding RNA is a group of genes that occupies the largest proportion in the human genome, and is a substance that regulates all developmental and metabolic processes in the human body in various ways, including protein gene regulation. Research on non-coding RNA is continuously expanding, and research to treat diseases by targeting such non-coding RNA is also in progress.
1. Functional study of non-coding RNA in vascular disease model
- Vascular smooth muscle cells play a pivotal role in cardiovascular diseases, and non-coding RNA shows abnormal expression patterns in various diseases including arteriosclerosis, myocardial infarction, and stroke.
- Through joint research with Professor Hyun Kook of the Department of Pharmacology at Chonnam National University Medical School, we are exploring ways to improve cardiovascular diseases by discovering non-coding RNAs that play an important role in cardiovascular disease.
2. Functional study of non-coding RNA in brain disease model
- The expression pattern of non-coding RNA changes in various cognitive disorders including dementia and depression.
- Through joint research with Professor Juhyun Song of the Department of Anatomy, Chonnam National University Medical School, we are studying how to improve the disease by identifying the functions of these non-coding RNAs in brain disease models and restoring their expression to normal.
3. Bioinformatics analysis of various transcriptome data
- In our laboratory, we are building a bioinformatics analysis algorithm that can analyze various transcriptome data, and through these applications, we are discovering protein genes and non-coding RNA genes that can be used as molecular markers in various disease models.
그림1 사람의 유전체 상에 존재하는 유전자들 그룹. 비암호화RNA(long noncoding RNA와 small noncoding RNA) 그룹이 단백질 유전자 그룹에 비해 더 큰 비율을 차지하고 있음
그림 다양한 비암호화RNA의 생성 과정과 작동 방식. 대표적인 비암호화RNA인 마이크로RNA, 긴 비암호화RNA, 원형 RNA들을 설명함
Publication
- 1. Song J, Kim YK*. (2021) Targeting non-coding RNAs for the treatment of retinal diseases. Mol Ther Nucleic Acids. 24:284.
- 2. Song J*, Kim YK*. (2021) Animal models for the study of depressive disorder. CNS Neurosci Ther. doi: 10.1111/cns.13622. (*co-corresponding authors)
- 3. Ryu J, Ahn Y, Kook H*, Kim YK*. (2020) The roles of non-coding RNAs in vascular calcification and opportunities as therapeutic targets. Pharmacol Ther. 8:107675. (*co-corresponding authors)
- 4. Choe N, Kwon DH, Ryu J, Shin S, Cho HJ, Joung H, Eom GH, Ahn Y, Park WJ, Nam KI, Kim YK*, Kook H*. (2020) miR-27a-3p Targets ATF3 to Reduce Calcium Deposition in Vascular Smooth Muscle Cells. Mol Ther Nucleic Acids. 22:627-639. (*co-corresponding authors)
- 5. Lim YH, Ryu J, Kook H*, Kim YK*. (2020) Identification of Long Noncoding RNAs Involved in Differentiation and Survival of Vascular Smooth Muscle Cells. Mol Ther Nucleic Acids. 22:209-221. (*co-corresponding authors)
- 6. Kim YK*, Kim YS, Kim S, Kim YJ, Ahn Y, Kook H. (2020) Comprehensive evaluation of differentially expressed non-coding RNAs identified during macrophage activation. Mol Immunol. 128:98-105. (*corresponding author)
- 7. Kim YK, Song J. (2020) Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain. Adv Nutr. 11:1686-1695.
- 8. Kim YK. (2020) RNA Therapy: Current Status and Future Potential. Chonnam Med J. 56:87-93.
- 9. Nam KI, Yoon G, Kim YK* and Song J*. (2020) Transcriptome Analysis of Pineal Glands in the Mouse Model of Alzheimer’s Disease. Front Mol Neurosci. 12:318. (*co-corresponding authors)
- 10. Ryu J, Kwon DH, Choe N, Shin S, Jeong G, Lim YH, Kim J, Park WJ, Kook H*, Kim YK*. (2020) Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification. Mol Ther Nucleic Acids. 19:31-41. (*co-corresponding authors)