본문
| Department | Anatomy |
|---|---|
| Major Field of Research | Neuroscience, Metabolic syndrome |
| juhyunsong@chonnam.ac.kr | |
| Homepage | medicine.jnu.ac.kr/xprofessor/index.php?mode=view&number=296&smode=1&div1=1&div2=10&div3=0 |
Research interests
Juhyun Song’s lab is performing researches on the relationship between metabolic disorders and neurodegenerative diseases.
1. The study on the role of adiponectin both in systemic metabolism and central nervous system
- Adiponectin as one of adipokines from adipocytes has been known to regulate glucose metabolism, lipid metabolism, inflammation, and cell viability mechanism. Adiponectin contributes to adipocyte differentiation and fat browning.
- In central nervous system, adiponectin has multiple functions including the improvement of brain insulin resistance, neurite outgrowth, and neuronal cell viability, and the regulation of microglia polarization against neuroinflammation. We investigate whether or not adiponectin is involved in neuroinflammation, synaptic plasticity, long term potentiation, and brain insulin resistance.
- Diabetes induced dementia is considered as the low level of adiponectin in blood. This mouse model showed the impairment of brain insulin resistance, the memory loss. Adiponectin leads to the improvement of cognitive decline in diabetes induced dementia and decreases neuroinflammaiton
2. The study on the role of glucagon like peptide-1 (GLP-1) in central nervous system
- GLP-1 as am incretin hormone is linked to the glucose metabolism, and insulin resistance. GLP-1 is secreted from gut L-cells and hindbrain specific neurons.
- In central nervous system, glp-1 contributes to the improvement of neurite outgrowth, synaptic plasticity, and neuronal survival mechanism
- We recently found that GLP-1 regulates mitochondrial function in neuron and promtote the stability of neural network and the spine maturation both in high fat diet mouse brain and in primary cultured neurons.
3. The study on the neuronal function and long non coding RNAs in Bile duct ligation model
- Bile duct ligation model reflects the hepatic encephalopathy. We investigated the mechanism of neuronal function in bile duct ligation mouse model.
- We are identifying causative long non coding RNAs responsible for neuronal dysfunction in bile duct ligation brain.
- In in vitro condition, we tried to find the cellular mechanisms on neuronal function related long non coding RNAs in bile duct ligation brain.
Publication
- 1.Gwangho Yoon, Young-Kook Kim, Juhyun Song* Glucagon-like peptide-1 suppresses neuroinflammation and improves neural structure. Pharmacological research. 2020 Feb;152:104615. * corresponding author
- 2.Juhyun Song*. Pineal gland dysfunction in Alzheimer's disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis. Molecular neurodegeneration. 2019 Jul 11;14(1):28.
- * corresponding author
- 3.Ming Wang, Jihoon Jo, Juhyun Song* Adiponectin improves long-term potentiation in the 5XFAD mouse brain. Scientific reports. 2019 Jun 20;9(1):8918. * co-corresponding authors
- 4.Oh Yoen Kim, Ji Yeon Chung, Juhyun Song* Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity. Pharmacological research 2019 Oct;148:104411. * corresponding author
- 5.Juhyun Song+, So Ra Yoon, Youn Kyoung Son, Woo Young Bang, Chang-Hwan Bae, Joo-Hong Yeo, Hyun-Jin Kim, Oh Yoen Kim. Carpinus turczaninowii Extract May Alleviate High Glucose-Induced Arterial Damage and Inflammation Antioxidants. 2019 Jun 11;8(6):172. + First author
- 6.Gwangho Yoon, Kyung A Cho, Juhyun Song*, Young-Kook Kim* Transcriptomic Analysis of High Fat Diet Fed Mouse Brain Cortex Frontiers in genetics 2019 Feb 19;10:83. * co-corresponding authors
- 7.Young-Kook Kim, Juhyun Song* The Role of Long Noncoding RNAs in Diabetic Alzheimer's Disease. Journal of clinical medicine. 2018 Nov 21;7(11):461 * corresponding author
- 8.Juhyun Song+, So Ra Yoon, Oh Yoen Kim. T allele at ADIPOQ rs1501299 G/T polymorphism is more susceptible to the influence of circulating adiponectin on arterial stiffness in nondiabetic men. Diabetology and metabolic syndrome 2018 Jun 4;10:44. + First author
- 9.Juhyun Song+, Seong-Min Choi, Daniel J Whitcomb, Byeong C Kim. Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity. Cell death and disease. 2017 Oct 12;8(10):e3102. + First author
- 10.Juhyun Song+, Young-Kook Kim Identification of the Role of miR-142-5p in Alzheimer's Disease by Comparative Bioinformatics and Cellular Analysis. Frontiers in molecular neurosciences 2017 Jul 18;10:227. + First author