본문
| Department | MRC |
|---|---|
| Major Field of Research | T cell immunobiology |
| jh_cho@chonnam.ac.kr | |
| Homepage |
Research interests
T cell immunity is a key component of adaptive immune system and has a broad impact on many aspects of human diseases, including infectious diseases, autoimmune diseases, and cancers. Therefore, exact understanding of T cell immunobiology is of immense importance to gain insights on the mechanistic basis of such diseases and the development of a potential therapeutic strategies. The main interest of our lab is to understand how T cell acquires functional heterogeneity and how such diverse behaviours are regulated in different immune contexts. The key research topics focused is as follows: i) to address a role of self-reactivity and homeostatic cytokines in shaping T cell functional heterogeneity; ii) to address underlying mechanism of the requirement of self-recognition for T cell homeostasis; and iii) to understand human CD8 T cell heterogeneity particularly in cancer patients and develop a predictive biomarker for the patients' response outcome after immunotherapies.
Publication
- 1. Kye YC, SM Park, BS Shim, J Firdous, G Kim, HW Kim, YJ Ju, CG Kim, CS Cho, DW Kim, JH Cho, MK Song, SH Han, and CH Yun (2019) Intranasal immunization with pneumococcal surface protein A in the presence of nanoparticle forming polysorbitol transporter adjuvant induces protective immunity against the Stroptococcus pneumoniae infection. Acta Biomaterialia 90, 362 (2019/05/19).
- 2. Hong JE, YC Kye, SM Park, IS Cheon, H Chu, BC Park, YM Park, J Chang, JH Cho, MK Song, SH Han, and CH Yun (2019) Alveolar macrophages treated with Bacillus Subtilis spore protect mice infected with respiratory syncytial virus A2. Front. Microbio. 10, 447 (2019/03/12).
- 3. Kwon YK, OK Park, JS Kim, JH Cho, CH Yun, and SH Han (2019) Cyclic dinucleotides inhibit osteoclast differentiation through STING-mediated interferon-b signaling. J Bone & Mineral Res. https://doi.org/10.1002/jbmr.3701 (2019/02/19)
- 4. Kim JH, JY Lee, KJ Cho, SW Hong, KS Kim, J Sprent, SH Im, CD Surh, and JH Cho (2018) Spontaneous proliferation of CD4+ T cells in RAG-deficient hosts promotes antigen-independent but IL-2-dependent strong proliferative response of naïve CD8+ T cells. Front. Immunol. 9, 1907. (2018/08/23)
- 5. Cho JH*, and J Sprent* (2018) TCR tuning of T cell subsets. Immunological Reviews, 283, 129. (2018/05) *Corresponding author.
- 6. Lee JY, JH Kim, J Yi, DE Kim, HO Kim, DH Han, J Sprent, YJ Lee, CD Surh, and JH Cho (2018) Phenotypic and functional changes of peripheral Ly6C+ T regulatory cells driven by conventional effector T cells. Front. Immunol. 9, 437. (2018/03/16)
- 7. Kim GR, MJ Gu, SJ Kim, KH Ko, YC Kye, CG Kim, JH Cho, WK Lee, KD Song, SH Han, and CH Yun (2018) Transcription Factor KLF10 Constrains IL-17-Committed Vg4+ gd T cells. Front. Immunol. 9, 196. (2018/02/28)
- 8. Kim HO, and JH Cho (2017) T cell’s sense of self: a role of self-recognition in shaping functional competence of naïve T cells. Immune Network. 17, 201. (2017/08)
- 9. Cho JH*, HO Kim, YJ Ju, YC Kye, GW Lee, SW Lee, CH Yun, N Bottini, K Webster, CC Goodnow, CD Surh, C King, and J Sprent* (2016) CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells. Nat. Commun. 7, 13373. (2016/11/14) *Corresponding author.
- 10. Nguyen HH, T Kim, SY Song, S Park, HH Cho, SH Jung, JS Ahn, HJ Kim, JJ Lee, HO Kim, JH Cho, and DH Yang (2016) Naïve CD8+ T cell derived tumor-specific cytotoxic effectors as a potential remedy for overcoming TGF-beta immunosuppression in the tumor microenvironment. Scientific Rep. 6, 1. (2016/06/16)
- 11. Corpuz TM, J Stolp, HO Kim, GV Pinget, DH Gray, JH Cho, J Sprent, and KE Webster (2016) Differential Responsiveness of Innate-like IL-17- and IFN-gamma-Producing gammadelta T Cells to Homeostatic Cytokines. J Immunol. 196, 645. (2016/01/15)