Shin, Myung Geun > Faculty

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RESEARCH

RESEARCH

RESEARCH

RESEARCH
Faculty

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Shin, Myung Geun
Department Laboratory Medicine
Major Field of Research Hematopathology, Molecular Diagnostics, Cytogenetics
E-mail mgshin@chonnam.ac.kr
Homepage kbluebio.com

학력

  • 1995. Chonnam National University School of Medicine (Doctorate)
  • 1992. Chonnam National University School of Medicine (Master's)
  • 1989. Chonnam National University College of Medicine (Bachelor's)

경력 및 해외 연수

  • 2004 - 2010. 09. Associate professor at Dept. of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital
  • 2008. 10. - 2011. 04. Chair, Institutional Review Board of Chonnam National University Hwasun Hospital
  • 2013. 04. - 2015. 05. Director, Education Research of Chonnam National University Hwasun Hospital
  • 2010. 10. - Present Professor (tenured) at Dept. of Laboratory Medicine, Chonnam National University Medical School and Chonnam National University Hwasun Hospital
  • 2017. 12. - 2020. 02. Director of Hospital Care of Chonnam National University Hwasun Hospital
  • 2020. 03. - Present Chief of Medical Clinic of Chonnam National University Hwasun Hospital

Research interests

 Professor Myung-Geun Shin's laboratory is conducting the following transitional studies for the identification of new molecular pathophysiology, discovery of companion diagnostic markers, and development of innovative anticancer drugs, focusing on mitochondria using clinical specimens obtained from patients with various blood diseases such as leukemia.

 

 

1. Identification of new molecular pathophysiology of blood cancer

- Although new molecular pathophysiology of blood cancers such as leukemia has been identified and new drugs have emerged, no game changers that can guarantee actual clinical effects have been found.

- Accordingly, my laboratory is conducting research on new pathophysiology and development of innovative anti-cancer drugs to conquer blood cancer with a precision medical approach by targeting mitochondria, which play a role as a power plant of cells and tissues as well as a center of apoptosis.

 

 

2. Discovering markers for intractable cancer companion diagnostics

- Companion diagnosis is made through markers of diagnostic value and therapeutic target. In my laboratory, a transitional study is conducted to discover useful companion diagnostic markers for the implementation of the companion diagnosis of intractable cancers such as aged leukemia and multiple myeloma.

- The next-generation genomic analysis platform that is well established and operated at the Chonnam National University Hwasun Hospital Precision Medicine Center (jointly operated by the Department of Laboratory Medicine and the Department of Pathology) is used to investigate the pathophysiology role of tumor molecules of the discovered companion diagnostic markers,

 

 

3. New innovative anticancer drug development

- We are conducting preclinical trials for approval of clinical trials for human application for KBB-CC1 and KBB-CC2, which are new anticancer active substances targeting the leukemia companion diagnostic markers discovered in our laboratory.

- We intend to develop innovative anticancer drugs that can be administered to elderly blood cancer patients by discovering natural substances with excellent anticancer action, synthesizing synthetic cancer-containing active substances that mimic them, and evaluating laboratory-level stability, efficacy, and pharmaceutical potential. To this end, in my laboratory, experiments with non-GLP level are in progress by discovering and synthesizing synthetic anticancer active substances that mimic KBB-N1 and KBB-N2.

수상경력

  • 2005 Young Travelers Awards, The 3rd Asian Hematology Session
  • 2007 Siemens Academic Award, The Fall Conference of the Korean Society for Laboratory Medicine
  • 2008 Best Adjudicator Award, Korean Society for Laboratory Medicine
  • 2008 Best Reseatch Award, The Korean Society of Hematology
  • 2009 Best Research Award, National Cancer Conquest Promotion R&D Project
  • 2016 - 2015 Marquis Who's Who in the World
  • 2016 Best Science Technology Paper Award, The Korean Federation of Science and Technology Societies
  • 2016 Academic Award, Korean Society for Genetic Diagnostics
  • 2017 Academic Award, The Korean Society for Laboratory Hematology
  • 2017 Academic Award, Korean Society for Laboratory Medicine

Publication

  • ∙ Mitochondrial DNA aberrations and pathophysiological implications in hematopoietic diseases, chronic inflammatory diseases, and cancers. Ann Lab Med 2015 Jan;35(1):1-14
  • ∙ BDNF promoter methylation associated with suicidal ideation in patients with breast cancer. Int J Psychiatry Med 2015;49(1):75-94
  • ∙ Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry-based VITEK MS system for the identification of Acinetobacter species from blood cultures: comparison with VITEK 2 and MicroScan systems. Ann Lab Med 2015 Jan;35(1):62-8
  • ∙ Antifungal susceptibilities of bloodstream isolates of Candida species from nine hospitals in Korea: application of new antifungal breakpoints and relationship to antifungal usage. PLos One 2015 Feb 23;10(2):e0118770
  • ∙ The cis-AB01 allele originated from the A105 allele, and not from the A102 allele. Ann Lab Med. 2015 Mar;35(2):270-80
  • ∙ Longitudinal associations between BDNF promoter methylation and late-life depression. Neurobiol Aging 2015 Apr;36(4): 1764.e1-1764-e7
  • ∙ Comparison of FcRγ-Deficient and CD57+ Natural Killer Cells Between Cord Blood and Adult Blood in the Cytomegalovirus-Endemic Korean Population. Ann Lab Med 2015 Jul;35(4):423-8
  • ∙ Seroepidemiology of Toxocariasis and Its Clinical Implications in Gwangju and Jeonnam-province, Korea. Ann Lab Med 2015 Jul;35(4):449-53
  • ∙ CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer. OnCol Rep 2015 Sep;34(3):1231-8
  • ∙ Immature teratoma and subsequent acute promyelocytic leukemia in a pediatric patient with XYY syndrome. Ann Lab Med. 2015 Sep;35(5):544-7
  • ∙ A novel cis-AB variant allele arising from a de novo nucleotide substitution c.796A>G (p.M266V) in the B glycosyltransferase gene. Transfus Med 2015 Oct;25(5):333-6
  • ∙ Longitudinal Study of BDNF Promoter Methylation and Depression in Breast Cancer. Psychiatry Investig 2015 Oct;12(4):523-31
  • ∙ 5-Azacytidine modulates interferon regulatory factor 1 in macrophages to exert a cardioprotective effect. Sci Rep 2015 Oct 29;5:15768
  • ∙ Molecular identification and amphotericin B susceptibility testing of clinical isolates of Aspergillus from 11 hospitals in Korea. Ann Lab Med 2015 Nov;35(6):602-10
  • ∙ Cryptic e1a2 BCR-ABL1 fusion with complex chromosomal abnormality in de novo myelodysplastic syndrome. Ann Lab Med 2015 Nov;35(6):643-6
  • ∙ Clinicopathological Implications of Mitochondrial Genome Alterations in Pediatric Acute Myeloid Leukemia. Ann Lab Med 2016 Mar;36(2):101-10
  • ∙ Resistance Mechanisms and Clinical Features of Fluconazole-Nonsusceptible Candida tropicalis Isolates Compared with Fluconazole-Less-Susceptible Isolates. Antimicrob Agents Chemother 2016 May 23;60(6):3653-61
  • ∙ A Novel KIT INDEL Mutation in Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1. Ann Lab Med 2016 Jul;36(4):371-4
  • ∙ Coexistence of JAK2 and CALR mutations and their clinical implications in patients with essential thrombocythemia. Oncotarget 2016 Aug 30;7(35):57036-57049
  • ∙ A novel PIGA mutation in a family with X-linked, early-onset epileptic encephalopathy. Brain Dev 2016 Sep;38(8):750-4
  • ∙ Progastrin-releasing peptide as a diagnostic and therapeutic biomarker of small cell lung cancer. J Thorac Dis 2016 Sep;8(9):2530-2537
  • ∙ Thalidomide-based induction regimens are as effective as bortezomib-based regimens in elderly patients with multiple myeloma with cereblon expression. Ann Hematol 2016 Oct;95(10):1645-51
  • ∙ Multiplex Real-Time PCR Assay Targeting Eight Parasites Customized to the Korean Population: Potential Use for Detection in Diarrheal Stool Samples from Gastroenteritis Patients. PLos One 2016 Nov 18;11(11):e0166957
  • ∙ First Case Report of Bacteremia Due to Catabacter hongkongensis in a Korean Patient. Ann Lab Med 2017 Jan;37(1):84-87
  • ∙ Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin. Sci Transl Med 2017 Feb 8;9(376)
  • ∙ Comparison of the Bruker Biotyper and VITEK MS Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Systems Using a Formic Acid Extraction Method to Identify Common and Uncommon Yeast Isolates. Ann Lab Med 2017 May;37(3):223-230
  • ∙ Evaluation of matrix-assisted laser desorption/ionization time-of-fight mass spectrometry for identification of 345 clinical isolates of Aspergillus species from 11 Korean hospitals: comparison with molecular identification. Diagn Microbiol Infect Dis 2017 Jan;87(1):28-31
  • ∙ β-catenin induces expression of prohibitin gene in acute leukemic cells. Oncol Rep 2017 Jun;37(6):3201-3208
  • ∙ HLA-A*24:02:01:09, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 Nov;90(5):304-305
  • ∙ HLA-DPB1*518:01, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 Nov;90(5):316-318
  • ∙ HLA-DPB1*519:01, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 Nov;90(5):318-319
  • ∙ HLA-B*40:302, a new allele identified by sequence-based typing in a Korean individual. HLA 2017 Dec;90(6):368-369
  • ∙ Identification of HLA-B*58:01:21, a novel allele in a Korean individual. HLA 2017 Dec;90(6):368-369
  • ∙ Antifungal susceptibilities to amphotericin B, triazoles and echinocandins of 77 clinical isolates of cryptic Aspergillus species in multicenter surveillance in Korea. Med Mycol 2018 Jun 1;56(4):501-505
  • ∙ Diversity of clinical isolates of Aspergillus terreus in antifungal susceptibilities, genotypes and virulence in Galleria mellonella model: Comparison between respiratory and ear isolates. PLoS One 2017 Oct 9;12(10):e0186086
  • ∙ The Impact of Tumor Necrosis Factor-α and Interleukin-1β Levels and Polymorphisms on Long-Term Stroke Outcomes. Eur Neurol 2018;79(1-2):38-44
  • ∙ STAT3 expression is associated with poor survival in non-elderly adult patients with newly diagnosed multiple myeloma. Blood Res 2017 Dec;52(4):293-299
  • ∙ Longitudinal associations between glucocorticoid receptor methylation and late-life depression. Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(Pt A):56-62
  • ∙ Identification of the novel HLA-B*15:18:01:04 in a Korean individual. HLA 2018 May 15
  • ∙ Molecular Diagnosis of Taenia saginata Tapeworm Infection in 2 Schoolchildren, Myanmar. Emerg Infect Dis 2018 Jun;24(6):1156-1158
  • ∙ Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function. Ann Lab Med 2018 Sep;38(5):395-401
  • ∙ Serum Copeptin Levels Predict Clinical Outcomes After Successful Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction. Ann Lab Med 2018 Nov;38(6):538-544
  • ∙ Next-generation sequencing-based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse. Blood 2018 Oct 11;132(15):1604-1613
  • ∙ Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea. Emerg Infect Dis 2018 Sep;24(9):1768-1770
  • ∙ Xpert MTB/RIF Assay as a Substitute for Smear Microscopy in an Intermediate-Burden Setting. Am J Respir Crit Care Med 2019 Mar 15;199(6):784-794
  • ∙ Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia. Blood Res 2018 Sep;53(3):240-249
  • ∙ Microsatellite Typing and Resistance Mechanism Analysis of Voriconazole-Resistant Aspergillus flavus Isolates in South Korean Hospitals. Antimicrob Agents Chemother 2019 Jan 29;63(2)
  • ∙ Methylation of the glucocorticoid receptor gene associated with depression in patients with acute coronary syndrome. Psychoneuroendocrinology 2019 Mar;101:42-49
  • ∙ Increased Prevalence of Thalassemia in Young People in Korea: Impact of Increasing Immigration. Ann Lab Med 2019 Mar;39(2):133-140
  • ∙ Candida auris Clinical Isolates from South Korea: Identification, Antifungal Susceptibility, and Genotyping. J Clin Microbiol 2019 Mar 28;57(4)
  • ∙ Remission clone in acute myeloid leukemia shows growth advantage after chemotherapy but is distinct from leukemic clone. Exp Hematol 2019 Jul;75:26-30
  • ∙ Fluoranthene-Induced Cytotoxicity and Direct Effect of Aryl Hydrocarbon Receptor Antagonist on Hematopoietic Stem Cell Differentiation. Ann Lab Med 2019 Nov;39(6):580-583
  • ∙ Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model. Bioorg Med Chem 2019 Oct 1;27(19):115014
  • ∙ A longitudinal study of the associations of BDNF genotype and methylation with poststroke anxiety. Int J Geriatr Psychiatry 2019 Nov;34(11):1706-1714
  • ∙ The MAKE Biomarker Discovery for Enhancing anTidepressant Treatment Effect and Response (MAKE BETTER) Study: Design and Methodology. Psychiatry Investig 2019 Oct;16(10):791-792
  • ∙ Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells. Blood Res 2019 Dec;54(4):253-261(corresponding)
  • ∙ Synergistic effects of depression and NR3C1 methylation on prognosis of acute coronary syndrome. Sci Rep 2020 Mar 26;10(1):5519
  • ∙ Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters. Mycobiology 2020;48(2):148-152(co-author)
  • ∙ Detection of the novel HLA-B allele, HLA-B*27:199, in a Korean individual. HLA 2020 Sep;96(3):345-347
  • ∙ The novel HLA-DRB1 allele, HLA-DRB1*01:108, identified in a Korean individual. HLA 2020 Sep;96(3):364-366
  • ∙ Coronavirus disease-19 and its hematological manifestations. Blood Res 2020 Jun 30;55(2):71-74
  • ∙ Evaluation of Two Commercial Broth Microdilution Methods Using Different Interpretive Criteria for the Detection of Molecular Mechanisms of Acquired Azole and Echinocandin Resistance in Four Common Candida Species. Antimicrob Agents Chemother 2020 Oct;64(11):e00740-20
  • ∙ RNA sequencing as an alternative tool for detecting measurable residual disease in core-binding factor acute myeloid leukemia. Sci Rep 2020 Nov;10(1):20119
  • ∙ MEF2D-BCL9 B-Lymphoblastic Leukemia Blast Morphology Dose Not Always Mimic Mature B-Cell Leukemia. J Pediatr Hematol Oncol 2020 Nov 23
  • ∙ Evaluation of a Fully Automated Antinuclear Antibody Indirect Immunofluorescence Assay in Routine Use. Front Immunol 2020 Dec 4;11:607541
  • ∙ Changing the frequency and spectra of chromosomal aberrations in Korean patients with acute leukemia in a tertiary care hospital. Blood Res 2020 Dec 31;55(4):225-245
  • ∙ The HLA-A*02:01:175 allele newly identified in a Korean hematopoietic stem cell donor by next-generation sequencing. HLA 2021 Jan;97(1):62-64
  • ∙ Performance Evaluation of VITEK MS for the Identification of a Wide Spectrum of Clinically Relevant Filamentous Fungi Using a Korean Collection. Ann Lab Med 2021 Mar 1;41(2):214-220
  • ∙ Utility of an Automatic Vision-Based Examination System (AVE-562) for the Detection of Clonorchis sinensis Eggs in Stool. Ann Lab Med 2021 Mar 1; 41(2):221-224
  • 2008 Bio-Medical Photonics 1st edition Chonnam National University Publisher
  • 2011 Hematology 2nd edition The Korean Society of Hematology publisher
  • 2014 Laboratory Medicine 5th edition The Korean Society of Laboratory Medicine publisher
  • 2021 Laboratory Medicine 6th edition The Korean Society of Laboratory Medicine publisher

학회활동

  • 2000 - Present Council Member, Korean Society for Laboratory Medicine
  • 2001 - Present Council Member, Korean Society of Hematology
  • 2004 - Present Regular Member, American Society of Hematology
  • 2009 - 2012 Treasurer, Korean Society of Genetic and Molecular Diagnosis
  • 2011 - 2012 Chairperson of Subcommittee for Diagnostic Hematology, Korean Society for Laboratory Medicine
  • 2011 - 2012 Direct of Academic, Korean Society for Laboratory Medicine
  • 2012 - 2018 Direct of Speciality Examination, Korean Society for Laboratory Medicine
  • 2017 - 2018 President, Honam Korean Society for Laboratory Medicine
  • 2018 - Present Direct of Legislation, Korean Society for Laboratory Medicine
  • 2018 - Present Editor-in-Chief, Blood Research (Official Journal of The Korean Society of Hematology)
  • 2021 - Present Vice President, The Korean Society for Laboratory Hematology