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| Department | Nuclear Medicine |
|---|---|
| Major Field of Research | pretargeting cancer therapy, thyroid cancer, molecular imaging |
| kwonsy@jnu.ac.kr | |
| Homepage |
Research interests
Seong Young Kwon’s lab is performing research on the following topics using microorganisms expressing pre-targeted proteins.
1. Development of a pre-targeted drug delivery system in a animal tumor model
- When a tumor targeting microorganism is administered into the body, it has a unique characteristic of targeting specifically only in tumor tissues.
- We are performing the research about a next-generation drug delivery system that could increase the tumor delivery efficiency of the therapeutic agent by directly expressing the pre-targeted protein in the tumor tissues and secondarily administering the therapeutic agents.
- Avidin was used as a pre-targeted protein and a biotinylated imaging agent was developed. In addition, we are conducting research on administering biotinylated therapeutic agents after visualizing tumor tissues using molecular imaging techniques.
2. Development of microbial visualization system in the body using pre-targeted protein
- Pre-targeted proteins such as avidin are expressed and could be fixed in microorganisms
- We are also performing the research to visualize the distribution of microorganisms in the body by using a biotinylated imaging agent after administering microorganisms to the body through various routes using nuclear medicine and molecular imaging techniques.
Fig. 1 Pre-targeted drug delivery system using avidin-expressing microorganisms
Publication
- Jeon S, Kwon SY*, Ryu YJ, Kang SR, Yoo SW, Cho SG, Kim J, Song HC, Sohn SJ, Bom HS, Min JJ. Combined role of lymph node ratio and serum thyroglobulin levels in predicting prognosis of papillary thyroid carcinoma. Nucl Med Commun. 2020 Aug;41(8):733-739. *corresponding author
- Mutsuddy P, Jeon S, Yoo SW, Zhang Y, Chowdhury MSA, Kim J, Song HC, Bom HS, Min JJ, Kwon SY*. Optimization of serum thyroglobulin measured at different time points for prognostic evaluation in differentiated thyroid carcinoma patients. Medicine (Baltimore). 2020 Apr;99(14):e19652. *corresponding author
- Yoo SW, Chowdhury MSA, Jeon S, Kang SR, Cho SG, Kim J, Lee C, Ryu YJ, Song HC, Bom HS, Min JJ, Kwon SY*. Optimization of Predictive Performance for the Therapeutic Response Using Iodine Scan-Corrected Serum Thyroglobulin in Patients with Differentiated Thyroid Carcinoma. Cancers (Basel). 2020 Jan 22;12(2):262. *corresponding author
- Yoo SW, Chowdhury MSA, Jeon S, Kang SR, Lee C, Jabin Z, Kim J, Cho SG, Song HC, Bom HS, Min JJ, Kwon SY*. Clinical Impact of F-18 FDG PET-CT on Biopsy Site Selection in Patients with Suspected Bone Metastasis of Unknown Primary Site. Nucl Med Mol Imaging. 2020 Aug;54(4):192-198. *corresponding author
- Jung TY, Jung S, Ryu HS, Kim IY, Jang WY, Moon KS, Lim SH, Kim DY, Kang SR, Min JJ, Bom HS, Kim SK, Kwon SY*. The Application of Magnetic Resonance Imaging-Deformed 11C-Methionine-Positron Emission Tomography Images in Stereotactic Radiosurgery. Stereotact Funct Neurosurg. 2019;97(4):217-224. *corresponding author
- Song M, Jeon S, Kang SR, Jabin Z, Yoo SW, Min JJ, Bom HS, Cho SG, Kim J, Song HC, Kwon SY*. Response Prediction of Altered Thyroglobulin Levels After Radioactive Iodine Therapy Aided by Recombinant Human Thyrotropin in Patients with Differentiated Thyroid Cancer. Nucl Med Mol Imaging. 2018 Aug;52(4):287-292. *corresponding author
- Park HJ, Min JJ, Bom HS, Kim J, Song HC, Kwon SY*. Early stimulated thyroglobulin for response prediction after recombinant human thyrotropin-aided radioiodine therapy. Ann Nucl Med. 2017 Oct;31(8):616-622. *corresponding author
- Jung TY, Min JJ, Bom HS, Jung S, Kim IY, Lim SH, Kim DY, Kwon SY*. Prognostic value of post-treatment metabolic tumor volume from 11C-methionine PET/CT in recurrent malignant glioma. Neurosurg Rev. 2017 Apr;40(2):223-229.*corresponding author
- Jung TY, Kim IY, Lim SH, Park KS, Kim DY, Jung S, Moon KS, Jang WY, Kang SR, Cho SG, Min JJ, Bom HS, Kwon SY*. Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected 11C-methionine
- uptake. EJNMMI Res. 2017 Dec;7(1):45. *corresponding author