본문
Koh, Jeong-Tae
| Department | Pharmacology and Dental Therapeutics |
|---|---|
| Major Field of Research | 1. Molecular mechanism of osteoblast/odontoblast differentiation 2. Bone regeneration with tissue engineering" |
| jtkoh@chonnam.ac.kr | |
| Homepage |
Research interests
Jeong-Tae Koh's lab is conducting extensive research on the homeostasis of hard tissues (bones, teeth), the pathophysiology and therapeutic approaches for overcoming hard-tissue diseases. We also have a lot of interest in the relationship between bone loss and oral/systemic diseases, including underlying molecular mechanisms and therapeutic intervention by using chemical substances. The main topics of current research are as follows.
1. The role of inflammasomes in hard-tissue biointerfaces
2. Bone loss in Diabetes/Osteoporosis/Aging process
3. Pathophysiology and therapeutic approach in periodontal bone loss (microbial and/or energy metabolites)
4. Development of bone regeneration technology
그림 . 연령증가에 따른 치조골 소실에서 인플라마좀 억제제 MCC 950의 효과
그림 연령에 따른 체내 구성 성분의 변화
그림 조직공학 기술을 응용한 뼈재생
Publication
- Zang Y, Song JH, Oh SH, Kim JW, Lee MN, Piao X, Yang JW, Kim OS, Kim TS, Kim SH, Koh JT. Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss. J Dent Res. 2020 Oct;99(11):1287-1295
- Son HJ, Lee MN, Kim Y, Choi H, Jeong BC, Oh SH, Kim JW, Kwon SH, Kim SH, Song SC, Lee SE, Koh JT. Bone Generation Following Repeated Administration of Recombinant Bone Morphogenetic Protein 2.
- Tissue Eng Regen Med. 2021 Feb;18(1):155-164.
- Kim JW, Oh SH, Lee MN, Song JH, Jeong BC, Yang JW, Piao X, Zang Y, Ryu JH, Koh JT. CUEDC2 controls osteoblast differentiation and bone formation via SOCS3-STAT3 pathway. Cell Death Dis. 2020 May 11;11(5):344.
- Lee MN, Song JH, Oh SH, Tham NT, Kim JW, Yang JW, Kim ES, Koh JT. The primary cilium directs osteopontin-induced migration of mesenchymal stem cells by regulating CD44 signaling and Cdc42 activation.
- Stem Cell Res. 2020 May;45:101799.
- Hwang HS, Kim JW, Oh SH, Song JH, Yang JW, Zang Y, Kim YH, Lee SE, Hwang YC, Koh JT. TLR5 activation induces expression of the pro-inflammatory mediator Urokinase Plasminogen Activator via NF-κB and MAPK signalling pathways in human dental pulp cells. Int Endod J. 2019 Oct;52(10):1479-1488.
- Lee MN, Hwang HS, Oh SH, Roshanzadeh A, Kim JW, Song JH, Kim ES, Koh JT. Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression. Exp Mol Med. 2018 Nov 5;50(11):1-16.
- Kim Y, Hur SW, Jeong BC, Oh SH, Hwang YC, Kim SH, Koh JT. The Fam50a positively regulates ameloblast differentiation via interacting with Runx2. J Cell Physiol. 2018 Feb;233(2):1512-1522.